Featured Publications
Systemic tumor targeting and killing by Sindbis viral vectors.
Tseng JC, Levin B, Hurtado A, Yee H, Perez de Castro I, Jimenez M, Shamamian P, Jin R, Novick RP, Pellicer A, Meruelo D.
Nat Biotechnol. 2004 Jan;22(1):70-7. Epub 2003 Nov 30.
Using sindbis viral vectors for specific detection and suppression of advanced ovarian cancer in animal models.
Tseng JC, Hurtado A, Yee H, Levin B, Boivin C, Benet M, Blank SV, Pellicer A, Meruelo D.
Cancer Res. 2004 Sep 15;64(18):6684-92.
Sindbis viral vectors transiently deliver tumor-associated antigens to lymph nodes and elicit diversified antitumor CD8+ T-cell immunity.
Granot T, Yamanashi Y, Meruelo D.
Mol Ther. 2014 Jan;22(1):112-22. doi: 10.1038/mt.2013.215. Epub 2013 Sep 12.
Systemically Administered Sindbis Virus in Combination with Immune Checkpoint Blockade Induces Curative Anti-tumor Immunity.
Scherwitzl I, Hurtado A, Pierce CM, Vogt S, Pampeno C, Meruelo D.
Mol Ther Oncolytics. 2018 May 3;9:51-63. doi: 10.1016/j.omto.2018.04.004. eCollection 2018 Jun 29.
Selected Publications
Molecular and metabolic pathways mediating curative treatment of a non-Hodgkin B cell lymphoma by Sindbis viral vectors and anti-4-1BB monoclonal antibody.
Yu M, Scherwitzl I, Opp S, Tsirigos A, Meruelo D.
J Immunother Cancer. 2019 Jul 15;7(1):185. doi: 10.1186/s40425-019-0664-3.
PMID: 31307539 [PubMed - in process]
Systemically Administered Sindbis Virus in Combination with Immune Checkpoint Blockade Induces Curative Anti-tumor Immunity.
Scherwitzl I, Hurtado A, Pierce CM, Vogt S, Pampeno C, Meruelo D.
Mol Ther Oncolytics. 2018 May 3;9:51-63. doi: 10.1016/j.omto.2018.04.004. eCollection 2018 Jun 29.
PMID: 29988525 [PubMed]
Screening strategies to identify HSP70 modulators to treat Alzheimer's disease.
Repalli J, Meruelo D.
Drug Des Devel Ther. 2015 Jan 7;9:321-31. doi: 10.2147/DDDT.S72165. eCollection 2015. Review.
PMID: 25609918 [PubMed - indexed for MEDLINE]
Sindbis viral vectors transiently deliver tumor-associated antigens to lymph nodes and elicit diversified antitumor CD8+ T-cell immunity.
Granot T, Yamanashi Y, Meruelo D.
Mol Ther. 2014 Jan;22(1):112-22. doi: 10.1038/mt.2013.215. Epub 2013 Sep 12.
PMID: 24025748 [PubMed - indexed for MEDLINE]
Structure-guided identification of a laminin binding site on the laminin receptor precursor.
Jamieson KV, Hubbard SR, Meruelo D.
J Mol Biol. 2011 Jan 7;405(1):24-32. doi: 10.1016/j.jmb.2010.10.028. Epub 2010 Oct 30. Review.
PMID: 21040730 [PubMed - indexed for MEDLINE]
Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak.
Venticinque L, Meruelo D.
Mol Cancer. 2010 Feb 12;9:37. doi: 10.1186/1476-4598-9-37.
PMID: 20152035 [PubMed - indexed for MEDLINE]
Enhanced specific delivery and targeting of oncolytic Sindbis viral vectors by modulating vascular leakiness in tumor.
Tseng JC, Granot T, DiGiacomo V, Levin B, Meruelo D.
Cancer Gene Ther. 2010 Apr;17(4):244-55. doi: 10.1038/cgt.2009.70. Epub 2009 Oct 2.
PMID: 19798121 [PubMed - indexed for MEDLINE]
Crystal structure of the human laminin receptor precursor.
Jamieson KV, Wu J, Hubbard SR, Meruelo D.
J Biol Chem. 2008 Feb 8;283(6):3002-5. Epub 2007 Dec 6.
PMID: 18063583 [PubMed - indexed for MEDLINE]
Using sindbis viral vectors for specific detection and suppression of advanced ovarian cancer in animal models.
Tseng JC, Hurtado A, Yee H, Levin B, Boivin C, Benet M, Blank SV, Pellicer A, Meruelo D.
Cancer Res. 2004 Sep 15;64(18):6684-92.
PMID: 15374985 [PubMed - indexed for MEDLINE]
Identification of amino acids of Sindbis virus E2 protein involved in targeting tumor metastases in vivo.
Hurtado A, Tseng JC, Boivin C, Levin B, Yee H, Pampeno C, Meruelo D.
Mol Ther. 2005 Nov;12(5):813-23. Epub 2005 Aug 16.
PMID: 16109508 [PubMed - indexed for MEDLINE]
Systemic tumor targeting and killing by Sindbis viral vectors.
Tseng JC, Levin B, Hurtado A, Yee H, Perez de Castro I, Jimenez M, Shamamian P, Jin R, Novick RP, Pellicer A, Meruelo D.
Nat Biotechnol. 2004 Jan;22(1):70-7. Epub 2003 Nov 30.
PMID: 14647305 [PubMed - indexed for MEDLINE]
In vivo antitumor activity of Sindbis viral vectors.
Tseng JC, Levin B, Hirano T, Yee H, Pampeno C, Meruelo D.
J Natl Cancer Inst. 2002 Dec 4;94(23):1790-802.
PMID: 12464651 [PubMed - indexed for MEDLINE]